| Spearfish, SD (City) |
| Spearman, TX (Town) |
| Spearsville, LA (Village) |
| Spearville, KS (Township) |
| Spearville, KS (City) |
| Speculator, NY (Village) |
| Speed, NC (Town) |
| Speed, KS (City) |
| Speedway, IN (Town) |
| Speedwell, ND (Township) |
| Speers, PA (Borough) |
| Spencer, SD (Town) |
| Spencer, OH (Village) |
| Spencer, ND (Township) |
| Spencer, NE (Village) |
