| Spencer Township, OH (Township) |
| Spencerport, NY (Village) |
| Spencerville, OH (Village) |
| Sperry, OK (Town) |
| Sperry Township, IA (Township) |
| Spice Valley, IN (Township) |
| Spiceland, IN (Township) |
| Spiceland, IN (Town) |
| Spicer, MN (City) |
| Spicewood Community Development District, FL (CDD) |
| Spickard, MO (City) |
| Spider Lake, WI (Town) |
| Spillertown, IL (Village) |
| Spillville, IA (City) |
| Spindale, NC (Town) |
